Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats
We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal re...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2018-06-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal reflex in rats, suggesting CB could induce visceral antinociception. Pretreatment with either the CB1 or CB2 antagonist potently blocked the centrally injected orexin-A-induced antinociceptive action against colonic distension while CB2 but not CB1 antagonist blocked the brain ghrelin-induced visceral antinociception. These results suggest that the cannabinoid signaling may be involved in the central orexin- or ghrelin-induced antinociceptive action in a different mechanistic manner. Keywords: Cannabinoid, Neuropeptide, Visceral sensation |
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| Item Description: | 1347-8613 10.1016/j.jphs.2018.06.001 |