Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats
We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal re...
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Elsevier,
2018-06-01T00:00:00Z.
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| 001 | doaj_1e7ea592b87b41cc90e233a1d9d2e9fd | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Toshikatsu Okumura |e author |
| 700 | 1 | 0 | |a Tsukasa Nozu |e author |
| 700 | 1 | 0 | |a Shima Kumei |e author |
| 700 | 1 | 0 | |a Masumi Ohhira |e author |
| 245 | 0 | 0 | |a Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats |
| 260 | |b Elsevier, |c 2018-06-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2018.06.001 | ||
| 520 | |a We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal reflex in rats, suggesting CB could induce visceral antinociception. Pretreatment with either the CB1 or CB2 antagonist potently blocked the centrally injected orexin-A-induced antinociceptive action against colonic distension while CB2 but not CB1 antagonist blocked the brain ghrelin-induced visceral antinociception. These results suggest that the cannabinoid signaling may be involved in the central orexin- or ghrelin-induced antinociceptive action in a different mechanistic manner. Keywords: Cannabinoid, Neuropeptide, Visceral sensation | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 230-232 (2018) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861318301002 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1e7ea592b87b41cc90e233a1d9d2e9fd |z Connect to this object online. |