A microdosing framework for absolute bioavailability assessment of poorly soluble drugs: A case study on cold‐labeled venetoclax, from chemistry to the clinic
Abstract This work presents an end‐to‐end approach for assessing the absolute bioavailability of highly hydrophobic, poorly water‐soluble compounds that exhibit high nonspecific binding using venetoclax as a model drug. The approach utilizes a stable labeled i.v. microdose and requires fewer resourc...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2022-01-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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