TP53 loss initiates chromosomal instability in fallopian tube epithelial cells

• Main Authors: Daniel Bronder (Author), Anthony Tighe (Author), Darawalee Wangsa (Author), Dali Zong (Author), Thomas J. Meyer (Author), René Wardenaar (Author), Paul Minshall (Author), Daniela Hirsch (Author), Kerstin Heselmeyer-Haddad (Author), Louisa Nelson (Author), Diana Spierings (Author), Joanne C. McGrail (Author), Maggie Cam (Author), André Nussenzweig (Author), Floris Foijer (Author), Thomas Ried (Author), Stephen S. Taylor (Author)
• Format: Book
• Published: The Company of Biologists, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN). However, direct causes of CIN, such as mutations in DNA replication and mitosis genes, are rare in HGSOC. We therefore as...