Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation

• Main Authors: Wei Liu (Author), Youyou He (Author), Zhongjie Guo (Author), Miaomiao Wang (Author), Xiaodong Han (Author), Hairui Jia (Author), Jin He (Author), Shanshan Miao (Author), Shengzheng Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The colchicine binding site of tubulin is a promising target for discovering novel antitumour agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate tubulin polymerisation inhibitory activity and broad-spectrum in vitro antitumour activity. In this study, structure...