Neolignans - honokiol and 4-O-methylhonokiol - as potential compounds counteracting diabetic complications - current state of knowledge

Diabetes mellitus is a chronic metabolic disease. It is characterized by hyperglycemia, which means an increased glucose levels in the serum. This disease can be a result of an insufficient insulin production by the pancreatic β cells, lack of tissue response to the action of this hormone or both th...

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Main Authors: Katarzyna Małgorzata Szałabska-Rąpała (Author), Weronika Borymska (Author), Ilona Kaczmarczyk-Żebrowska (Author)
Format: Book
Published: Polish Pharmaceutical Society, 2022-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Katarzyna Małgorzata Szałabska-Rąpała  |e author 
700 1 0 |a Weronika Borymska  |e author 
700 1 0 |a Ilona Kaczmarczyk-Żebrowska  |e author 
245 0 0 |a Neolignans - honokiol and 4-O-methylhonokiol - as potential compounds counteracting diabetic complications - current state of knowledge 
260 |b Polish Pharmaceutical Society,   |c 2022-12-01T00:00:00Z. 
500 |a 0014-8261 
500 |a 10.32383/farmpol/158472 
520 |a Diabetes mellitus is a chronic metabolic disease. It is characterized by hyperglycemia, which means an increased glucose levels in the serum. This disease can be a result of an insufficient insulin production by the pancreatic β cells, lack of tissue response to the action of this hormone or both these states occurring together. In the course of diabetes a disturbed metabolism of carbohydrates, proteins and lipids is observed. These disorders are often accompanied by chronic oxidative stress. Treatment of type 2 diabetes is based on the use of synthetic oral antidiabetic drugs. These drugs provide good glycemic control in the diabetics' body and improve their quality of life, however, they are not without side effects. Therefore, a comprehensive approach to the patient and additional implementation of compounds that allow to reduce the negative effects of oxidative stress and limit the occurrence of diabetic complications in the process of their treatment seem promising. The scientific world is particularly interested in plants with antioxidant properties. Honokiol is a polyphenolic compound from the neolignans group that can be found in the bark of various magnolia species. Both honokiol and 4-O-methylhonokiol are known for their pro-health properties and multidirectional action on the body, including the glycemic control and restoration of proper lipid metabolism. Therefore, this review focuses on arranging the available scientific literature, covering the issues of the influence of neolignans: honokiol and 4-O-methylhonokiol on the health of a patient suffering from type 2 diabetes and its complications. Data collected in this manuscript shows a beneficial effect of these compounds on the organs most exposed to diabetic complications - including the pancreas, heart muscle or kidneys, as well as the prevention of excessive obesity in the context of affecting the white adipose tissue. After an in-depth analysis of many scientific articles, it can be deduced that these compounds may prove to be promising agents supporting conventional therapies with antidiabetic drugs in the treatment of type 2 diabetes and its accompanying diseases. 
546 |a PL 
690 |a diabetes 
690 |a diabetic complications 
690 |a honokiol 
690 |a antidiabetic properties 
690 |a 4-o-methylhonokiol 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Farmacja Polska, Vol 78, Iss 10, Pp 551-564 (2022) 
787 0 |n https://www.ptfarm.pl/download/?file=File%2FFarmacja+Polska%2F2022%2F10%2F01_OG_Neolignany_n.pdf 
787 0 |n https://doaj.org/toc/0014-8261 
856 4 1 |u https://doaj.org/article/1ee66ea4a27a44ab9d5b76ab7ea62a3e  |z Connect to this object online.