Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and Inducing In Vivo Hypotensive Effect

• Autors principals: Juan A. Rubiolo (Autor), Emilio Lence (Autor), Concepción González-Bello (Autor), María Roel (Autor), José Gil-Longo (Autor), Manuel Campos-Toimil (Autor), Eva Ternon (Autor), Olivier P. Thomas (Autor), Antonio González-Cantalapiedra (Autor), Henar López-Alonso (Autor), Mercedes R. Vieytes (Autor), Luis M. Botana (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Crambescins are guanidine alkaloids from the sponge Crambe crambe. Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers. We studied and compared the in vitro, in vivo, and in silico effects of some crambescine A and C analogs. HepG2 gene expression was analyz...