Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer

• Main Authors: Xiaojie Chu (Author), Seungmin Shin (Author), Du-San Baek (Author), Liyong Zhang (Author), Alex Conard (Author), Megan Shi (Author), Ye-Jin Kim (Author), Cynthia Adams (Author), Maggie Hines (Author), Xianglei Liu (Author), Chuan Chen (Author), Zehua Sun (Author), Dontcho V. Jelev (Author), John W. Mellors (Author), Dimiter S. Dimitrov (Author), Wei Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prostate stem cell antigen (PSCA) is expressed in all stages of prostate cancer, including in advanced androgen-independent tumors and bone metastasis. PSCA may associate with prostate carcinogenesis and lineage plasticity in prostate cancer. PSCA is also a promising theranostic marker for a variety...