Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies

• Main Authors: Alice Hoeller (Author), Laura Ehrlich (Author), Michaela Golic (Author), Florian Herse (Author), Frank H. Perschel (Author), Monika Siwetz (Author), Wolfgang Henrich (Author), Ralf Dechend (Author), Berthold Huppertz (Author), Stefan Verlohren (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objective: To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF. Methods: Placental tissues and maternal blood samples from six cases of preeclampsia, seven IUGR, and six age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. Results: Neither placental PlGF mRNA and protein expression nor placental villous trophoblast expression intensity of PlGF was altered by placental dysfunction. Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.

Item Description

1064-1955
1525-6065
10.1080/10641955.2016.1273363