Nobiletin ameliorates glucose tolerance by protecting against β-cell loss in type-2 diabetic db/db mice

Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes. Our previous in vitro study demonstrated the insulinotropic and anti-apoptotic effects of nobiletin in pancreati...

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Main Authors: Yukiko K. Kaneko (Author), Yuki Tara (Author), Stella Amarachi Ihim (Author), Moe Yamamoto (Author), Megumi Kaji (Author), Tomohisa Ishikawa (Author)
Format: Book
Published: Elsevier, 2022-11-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_1f45d57433f343509be7c2f6f45b2511
042 |a dc 
100 1 0 |a Yukiko K. Kaneko  |e author 
700 1 0 |a Yuki Tara  |e author 
700 1 0 |a Stella Amarachi Ihim  |e author 
700 1 0 |a Moe Yamamoto  |e author 
700 1 0 |a Megumi Kaji  |e author 
700 1 0 |a Tomohisa Ishikawa  |e author 
245 0 0 |a Nobiletin ameliorates glucose tolerance by protecting against β-cell loss in type-2 diabetic db/db mice 
260 |b Elsevier,   |c 2022-11-01T00:00:00Z. 
500 |a 2667-0313 
500 |a 10.1016/j.phyplu.2022.100367 
520 |a Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes. Our previous in vitro study demonstrated the insulinotropic and anti-apoptotic effects of nobiletin in pancreatic β-cells. These effects of nobiletin are postulated to be responsible for its anti-diabetic activity. Purpose: We evaluated the anti-diabetic effects of nobiletin on pancreatic β-cells of type 2 diabetic db/db mice. Methods: Nobiletin was filled into an osmotic pump and implanted subcutaneously in the back of db/db mice for 2 weeks with continuous administration. The mice were then used for the experiments to elucidate the in vivo effects of nobiletin on glucose intolerance. Results: The continuous subcutaneous administration of nobiletin using osmotic pumps significantly reduced blood glucose levels in non-fasting state and during an oral glucose tolerance test. The nobiletin administration also ameliorated insulin sensitivity determined by insulin tolerance test, which was likely due to a reduction of white adipose tissue weight. In addition, β-cell mass was significantly larger in nobiletin-administered db/db mice compared to vehicle-administered db/db mice. These results suggest that continuous administration of nobiletin ameliorates glucose tolerance in type 2 diabetes, which is mediated by improving not only insulin resistance but also insulin secretion, the latter being due to protection against β-cell loss in diabetes. Conclusion: Nobiletin would have a valuable effect on the prevention of type 2 diabetes. 
546 |a EN 
690 |a Pancreatic β-cells 
690 |a β-cell mass 
690 |a Insulin secretion 
690 |a Insulin sensitivity 
690 |a Nobiletin 
690 |a Other systems of medicine 
690 |a RZ201-999 
655 7 |a article  |2 local 
786 0 |n Phytomedicine Plus, Vol 2, Iss 4, Pp 100367- (2022) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S2667031322001464 
787 0 |n https://doaj.org/toc/2667-0313 
856 4 1 |u https://doaj.org/article/1f45d57433f343509be7c2f6f45b2511  |z Connect to this object online.