Nobiletin ameliorates glucose tolerance by protecting against β-cell loss in type-2 diabetic db/db mice
Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes. Our previous in vitro study demonstrated the insulinotropic and anti-apoptotic effects of nobiletin in pancreati...
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Elsevier,
2022-11-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_1f45d57433f343509be7c2f6f45b2511 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Yukiko K. Kaneko |e author |
700 | 1 | 0 | |a Yuki Tara |e author |
700 | 1 | 0 | |a Stella Amarachi Ihim |e author |
700 | 1 | 0 | |a Moe Yamamoto |e author |
700 | 1 | 0 | |a Megumi Kaji |e author |
700 | 1 | 0 | |a Tomohisa Ishikawa |e author |
245 | 0 | 0 | |a Nobiletin ameliorates glucose tolerance by protecting against β-cell loss in type-2 diabetic db/db mice |
260 | |b Elsevier, |c 2022-11-01T00:00:00Z. | ||
500 | |a 2667-0313 | ||
500 | |a 10.1016/j.phyplu.2022.100367 | ||
520 | |a Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes. Our previous in vitro study demonstrated the insulinotropic and anti-apoptotic effects of nobiletin in pancreatic β-cells. These effects of nobiletin are postulated to be responsible for its anti-diabetic activity. Purpose: We evaluated the anti-diabetic effects of nobiletin on pancreatic β-cells of type 2 diabetic db/db mice. Methods: Nobiletin was filled into an osmotic pump and implanted subcutaneously in the back of db/db mice for 2 weeks with continuous administration. The mice were then used for the experiments to elucidate the in vivo effects of nobiletin on glucose intolerance. Results: The continuous subcutaneous administration of nobiletin using osmotic pumps significantly reduced blood glucose levels in non-fasting state and during an oral glucose tolerance test. The nobiletin administration also ameliorated insulin sensitivity determined by insulin tolerance test, which was likely due to a reduction of white adipose tissue weight. In addition, β-cell mass was significantly larger in nobiletin-administered db/db mice compared to vehicle-administered db/db mice. These results suggest that continuous administration of nobiletin ameliorates glucose tolerance in type 2 diabetes, which is mediated by improving not only insulin resistance but also insulin secretion, the latter being due to protection against β-cell loss in diabetes. Conclusion: Nobiletin would have a valuable effect on the prevention of type 2 diabetes. | ||
546 | |a EN | ||
690 | |a Pancreatic β-cells | ||
690 | |a β-cell mass | ||
690 | |a Insulin secretion | ||
690 | |a Insulin sensitivity | ||
690 | |a Nobiletin | ||
690 | |a Other systems of medicine | ||
690 | |a RZ201-999 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Phytomedicine Plus, Vol 2, Iss 4, Pp 100367- (2022) | |
787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2667031322001464 | |
787 | 0 | |n https://doaj.org/toc/2667-0313 | |
856 | 4 | 1 | |u https://doaj.org/article/1f45d57433f343509be7c2f6f45b2511 |z Connect to this object online. |