A 3-year-old child with multifocal (thoracoabdominal) primary neuroblastoma: A case report and literature review

• Main Authors: Ayesha Rahmat (Author), Swaminathan Keerthivasagam (Author), Sajid Qureshi (Author), Puja Bathala (Author), Mukta Ramadwar (Author), Gramani Arumugam Vasugi (Author), Harshavardhan Mahalingam (Author), Vasundhara Patil (Author), Dhaarani Jayaraman (Author), Julius Xavier Scott (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Introduction: Multifocal primary neuroblastoma in the non-infantile age group is rare, posing challenges in risk stratification and surgery. Case report: A 3-year-old girl presented with an abdominal mass and elevated urinary vanillylmandelic acid (218 mg/l). Positron emission tomography - computed tomography showed fluorodeoxyglucose-avid masses in the left suprarenal and posterior mediastinum with regional paraortic nodes. A biopsy of the suprarenal and thoracic masses was suggestive of ganglioneuroblastoma and ganglioneuroma. She was stratified as an intermediate risk, with the bone marrow being uninvolved and non-amplified MYCN. Gross tumor resection was achieved at all the sites after 2 cycles of neoadjuvant chemotherapy. She received 2 more cycles of adjuvant chemotherapy and has been disease-free for 3 years. Conclusion: Multifocal primaries in the non-infantile age group have favorable biological features and a good outcome.

Item Description

2468-1245
10.1016/j.phoj.2024.04.004