Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon-α inhibition

• Main Authors: Yishan Ye (Author), Laure Ricard (Author), Lama Siblany (Author), Nicolas Stocker (Author), Frédéric De Vassoigne (Author), Eolia Brissot (Author), Baptiste Lamarthée (Author), Arsène Mekinian (Author), Mohamad Mohty (Author), Béatrice Gaugler (Author), Florent Malard (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arsenic trioxide (As2O3) is recently found to have therapeutic potential in systemic sclerosis (SSc), a life-threatening multi-system fibrosing autoimmune disease with type I interferon (IFN-I) signature. Chronically activated plasmacytoid dendritic cells (pDCs) are responsible for IFN-I secretion a...