Drug Reaction with Eosinophilia and Systemic Symptoms Induced by Diosmin and Hesperidin: A Case Report

Pasita Palakornkitti, Teerapong Rattananukrom Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Teerapong Rattananukrom, Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hosp...

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Main Authors: Palakornkitti P (Author), Rattananukrom T (Author)
Format: Book
Published: Dove Medical Press, 2024-05-01T00:00:00Z.
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Summary:Pasita Palakornkitti, Teerapong Rattananukrom Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Teerapong Rattananukrom, Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand, Tel +662-201-1141, Fax +662-201-1211, Email teerpongrattananukrom@gmail.comAbstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse reaction which exhibits a diverse range of presentations. We described a 48-year-old man diagnosed with acute generalized exanthematous pustulosis (AGEP)-like DRESS following the administration of diosmin and hesperidin. To our knowledge, diosmin and hesperidin-induced DRESS are exceptionally rare. This aims to raise awareness of potential severe cutaneous side effects in patients taking these agents.Keywords: chronic venous insufficiency, daflon, facial edema, flavonoid, severe cutaneous adverse reactions
Item Description:1178-7015