M1 cholinergic signaling in the brain modulates cytokine levels and splenic cell sub-phenotypes following cecal ligation and puncture

• Main Authors: Mabel N. Abraham (Author), Ana Nedeljkovic-Kurepa (Author), Tiago D. Fernandes (Author), Omar Yaipen (Author), Mariana R. Brewer (Author), Daniel E. Leisman (Author), Matthew D. Taylor (Author), Clifford S. Deutschman (Author)
• Format: Book
• Published: BMC, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, administration of endotoxin to mice decreased activity of the vagus anti-inflammatory reflex. Treatment with the centrally-acting M1 muscarinic acetylcholine (AC...