Aggressive Natural Killer Cell Leukemia in an Adolescent Patient: A Case Report and Literature Review
Aggressive natural killer cell leukemia (ANKL) is a rare malignant tumor, especially uncommon in children. ANKL has very aggressive clinical course and bad prognosis and is usually caused by Epstein-Barr virus infection. ANKL often has clinical manifestations of hemophagocytic lymphohistiocytosis (H...
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Frontiers Media S.A.,
2022-05-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_1f76fd90fe974c59a3a3a8282b96ae3f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Rong Yang |e author |
| 700 | 1 | 0 | |a Rong Yang |e author |
| 700 | 1 | 0 | |a Yuan Ai |e author |
| 700 | 1 | 0 | |a Yuan Ai |e author |
| 700 | 1 | 0 | |a Chuan Liu |e author |
| 700 | 1 | 0 | |a Chuan Liu |e author |
| 700 | 1 | 0 | |a Xiaoxi Lu |e author |
| 700 | 1 | 0 | |a Xiaoxi Lu |e author |
| 245 | 0 | 0 | |a Aggressive Natural Killer Cell Leukemia in an Adolescent Patient: A Case Report and Literature Review |
| 260 | |b Frontiers Media S.A., |c 2022-05-01T00:00:00Z. | ||
| 500 | |a 2296-2360 | ||
| 500 | |a 10.3389/fped.2022.829927 | ||
| 520 | |a Aggressive natural killer cell leukemia (ANKL) is a rare malignant tumor, especially uncommon in children. ANKL has very aggressive clinical course and bad prognosis and is usually caused by Epstein-Barr virus infection. ANKL often has clinical manifestations of hemophagocytic lymphohistiocytosis (HLH) and can be easily treated as HLH, which might complicate this aggressive disease. Here we report an ANKL in adolescent whose clinical presentation was highly aggressive and response to L-asparaginase containing chemotherapy was very bad. Early-onset Flow cytometry of peripheral blood and bone marrow help make the diagnosis. | ||
| 546 | |a EN | ||
| 690 | |a aggressive natural killer cell leukemia | ||
| 690 | |a children | ||
| 690 | |a Epstein-Barr virus | ||
| 690 | |a hemophagocytic lymphohistiocytosis | ||
| 690 | |a case report | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pediatrics, Vol 10 (2022) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fped.2022.829927/full | |
| 787 | 0 | |n https://doaj.org/toc/2296-2360 | |
| 856 | 4 | 1 | |u https://doaj.org/article/1f76fd90fe974c59a3a3a8282b96ae3f |z Connect to this object online. |