"Dual Anta-Inhibitors" of the A_2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

• Main Authors: Andrea Spinaci (Author), Michela Buccioni (Author), Daniela Catarzi (Author), Chang Cui (Author), Vittoria Colotta (Author), Diego Dal Ben (Author), Eleonora Cescon (Author), Beatrice Francucci (Author), Ilenia Grieco (Author), Catia Lambertucci (Author), Gabriella Marucci (Author), Davide Bassani (Author), Matteo Pavan (Author), Flavia Varano (Author), Stephanie Federico (Author), Giampiero Spalluto (Author), Stefano Moro (Author), Rosaria Volpini (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on a screening of a chemical library of A_2A adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were synthesized and tested for their ability to inhibit the activity of the enzyme casein kinase 1 delta (CK1δ) and to bind adenosine...