Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes

• Main Authors: Montserrat A. de la Rosa Rodriguez (Author), Lei Deng (Author), Anne Gemmink (Author), Michel van Weeghel (Author), Marie Louise Aoun (Author), Christina Warnecke (Author), Rajat Singh (Author), Jan Willem Borst (Author), Sander Kersten (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Storage of triglycerides in lipid droplets is governed by a set of lipid droplet-associated proteins. One of these lipid droplet-associated proteins, hypoxia-inducible lipid droplet-associated (HILPDA), was found to impair lipid droplet breakdown in macrophages and cancer cells by inhibit...