VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans

• Main Authors: Rita Schüler (Author), Nicole Seebeck (Author), Martin A. Osterhoff (Author), Veronica Witte (Author), Agnes Flöel (Author), Andreas Busjahn (Author), Alexander Jais (Author), Jens C. Brüning (Author), Turid Frahnow (Author), Stefan Kabisch (Author), Olga Pivovarova (Author), Silke Hornemann (Author), Michael Kruse (Author), Andreas F.H. Pfeiffer (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Reduction of brain glucose transporter GLUT1 results in severe neurological dysfunction. VEGF is required to restore and maintain brain glucose uptake across the blood brain barrier via GLUT1, which was shown to be acutely diminished in response to a high fat diet (HFD) in mice. The genet...