Hematuria during prolonged administration of ketamine to treat bronchospasm and respiratory failure in a toddler.
Given its ability to provide both sedation and analgesia, ketamine remains a popular agent for various clinical sce- narios in infants and children including the induction of anesthesia, procedural sedation, ICU sedation, and the treatment of pain. Additionally, it has been used as a ther- apeutic a...
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| Main Authors: | , , |
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| Format: | Book |
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Pediatric Anesthesia and Critical Care Journal,
2023-08-01T00:00:00Z.
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| Summary: | Given its ability to provide both sedation and analgesia, ketamine remains a popular agent for various clinical sce- narios in infants and children including the induction of anesthesia, procedural sedation, ICU sedation, and the treatment of pain. Additionally, it has been used as a ther- apeutic agent in the treatment of status asthmaticus and status epilepticus. In general, it has a wide therapeutic in- dex with a limited adverse effect profile that most com- monly includes tachycardia, hypertension, sialorrhea, and emergence delirium. We present a 2-year-old child with a complex past medical history, including extreme prematurity and chronic lung disease including bron- chopulmonary dysplasia (BPD), who developed hematuria following the prolonged administration of ket- amine infusion in the ICU setting. The adverse effect pro- file of ketamine is reviewed, previous reports of hematu- ria following its use presented, and potential mechanisms of this adverse effect discussed. |
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| Item Description: | 10.14587/paccj.2023.15 2281-8421 |