Increment in vitamin D level and bone mineral accrual in children with vitamin D deficiency

• Main Authors: Yashwant Kumar Rao (Author), Tanu Midha (Author), Satyajeet Singh (Author), Anurag Bajpai (Author), Amita Tilak (Author)
• Format: Book
• Published: Korean Pediatric Society, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

PurposeTo compare different regimens of vitamin D with respect to its serum increment levels and bone mineral accrual in vitamin D-deficient children.MethodsChildren identified as being vitamin D deficient (serum levels<20 ng/mL) were divided into 3 treatment groups by stratified block randomization (group 1, 4,000 IU/day of vitamin D3 plus 50 mg/kg/day calcium for 12 weeks; group 2, 30,000 IU/wk of vitamin D3 plus 50 mg/kg/day calcium for 12 weeks; and group 3, 300,000 IU of vitamin D3 once intramuscularly plus 50 mg/kg/day calcium). After regimen completion, each child received a maintenance dose of 400 IU/day vitamin D3 plus 50 mg/kg/day calcium. Their serum vitamin D level was measured after 3 and 12 months. Total body less head bone mineral concentration (BMC) and total body less head bone mineral density (BMD) were measured after 12 months.ResultsThe mean increment in serum vitamin D levels from baseline to 3 months was significantly higher in group 3 than in groups 1 and 2, but the levels from 3 to 12 months were almost similar among all 3 groups. There were no significant differences among the 3 groups with respect to percentage increase of BMD and BMC.ConclusionThe injectable form of vitamin D was more efficacious than the oral forms in increasing the serum level to the normal range. All 3 regimens were equally effective in increasing the BMC and BMD. The 400 IU/day maintenance dose was sufficient to keep the serum level within the normal range.

Item Description

1738-1061
2092-7258
10.3345/kjp.2016.59.7.292