Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays.

• Main Authors: Sarah L Berry (Author), Hamza Hameed (Author), Anna Thomason (Author), Marissa L Maciej-Hulme (Author), Somaia Saif Abou-Akkada (Author), Paul Horrocks (Author), Helen P Price (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging. New therapeutics are urgently needed, however, screening...