A perspective on the current use of the phase distribution model for predicting milk‐to‐plasma drug concentration ratio
Abstract The phase distribution model, proposed by Atkinson and Begg in 1990, has been widely used for predicting breastmilk‐to‐plasma drug concentration ratio. However, misrepresentations of the equations have been noted in recent publications. In this perspective, we revisit the derivation of the...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2022-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Abstract The phase distribution model, proposed by Atkinson and Begg in 1990, has been widely used for predicting breastmilk‐to‐plasma drug concentration ratio. However, misrepresentations of the equations have been noted in recent publications. In this perspective, we revisit the derivation of the equations and provide an R/Shiny interface for the model with a view to helping scientists in this field acquire in‐depth understanding of the theoretical background and implementation of the model. |
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| Item Description: | 2163-8306 10.1002/psp4.12865 |