A perspective on the current use of the phase distribution model for predicting milk‐to‐plasma drug concentration ratio

• Main Authors: Mian Zhang (Author), Caroline Sychterz (Author), Ming Chang (Author), Lu Huang (Author), Brian J. Schmidt (Author), Lu Gaohua (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The phase distribution model, proposed by Atkinson and Begg in 1990, has been widely used for predicting breastmilk‐to‐plasma drug concentration ratio. However, misrepresentations of the equations have been noted in recent publications. In this perspective, we revisit the derivation of the...