Multispecies-targeting siRNAs for the modulation of JAK1 in the skin

• Main Authors: Qi Tang (Author), Katherine Y. Gross (Author), Hassan H. Fakih (Author), Samuel O. Jackson (Author), Mohammad Zain U.I. Abideen (Author), Kathryn R. Monopoli (Author), Carine Blanchard (Author), Claire Bouix-Peter (Author), Thibaud Portal (Author), John E. Harris (Author), Anastasia Khvorova (Author), Julia F. Alterman (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Identifying therapeutic oligonucleotides that are cross-reactive to experimental animal species can dramatically accelerate the process of preclinical development and clinical translation. Here, we identify fully chemically-modified small interfering RNAs (siRNAs) that are cross-reactive to Janus ki...