Inhibition of KCa2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia

• Main Authors: Jonas Goldin Diness (Author), Lea Abildgaard (Author), Sofia Hammami Bomholtz (Author), Mark Alexander Skarsfeldt (Author), Nils Edvardsson (Author), Ulrik S. Sørensen (Author), Morten Grunnet (Author), Bo Hjorth Bentzen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundHypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents.Small conductance Ca2+-activated K+-channels (KCa2) are a promisi...