Coeliac Disease Complicating to B Cell Lymphoma and Enterocolic Fistula
We describe the case of 66 year old male, known case of COPD and type II diabetes mellitus, with a diagnosis of coeliac disease confirmed by the elevated titers of antigliadin and antiendomysium IgG antibodies together with partial villous atrophy in jejunal histology, complicating to diffuse large...
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| Main Authors: | , |
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| Format: | Book |
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KARACHI MEDICAL AND DENTAL COLLEGE,
2019-03-01T00:00:00Z.
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| Summary: | We describe the case of 66 year old male, known case of COPD and type II diabetes mellitus, with a diagnosis of coeliac disease confirmed by the elevated titers of antigliadin and antiendomysium IgG antibodies together with partial villous atrophy in jejunal histology, complicating to diffuse large B cell lymphoma presented as enterocolic fistula. Laparotomy was performed which included gastrojejun- ostomy to bypass the fistula, ileo-ileal anastomosis to prevent obstruction, and end-transverse colos- tomy. Histology was taken from fistulous tract following laparotomy suspected high-grade non-Hodgkin's lymphoma. Further supplementary reports showed immunoperoxidase studies that the tumor cells are strongly positive for LCA and negative for CD30 and S100. These findings are sug- gestive of high grade non Hodgkins lymphoma which is confirmed by immunohistochemistry results. The biopsy showed high proliferation and soft tissue infiltration by diffuse large B-cell lymphoma which shows extensive apoptosis secondary to a complication of coeliac disease presenting as enterocoloc fistula. |
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| Item Description: | 10.58397/ashkmdc.v24i1.27 1563-3241 |