Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System

• Main Authors: Alessandro Cannavo (Author), Daniela Liccardo (Author), Klara Komici (Author), Graziamaria Corbi (Author), Claudio de Lucia (Author), Grazia D. Femminella (Author), Andrea Elia (Author), Leonardo Bencivenga (Author), Nicola Ferrara (Author), Walter J. Koch (Author), Nazareno Paolocci (Author), Giuseppe Rengo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The sphingosine kinases 1 and 2 (SphK1 and 2) catalyze the phosphorylation of the lipid, sphingosine, generating the signal transmitter, sphingosine 1-phosphate (S1P). The activation of such kinases and the subsequent S1P generation and secretion in the blood serum of mammals represent a major check...