STUDY ON THE EFFECTS OF MELATONIN ADMINISTRATION ON INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH TYPE II DIABETES AND PERIODONTAL DISEASE

• Main Authors: Diana-Maria Anton (Author), Irina-Georgeta Sufaru (Author), Maria-Alexandra Martu (Author), Raluca Mocanu (Author), Ionut Luchian (Author), Monica-Mihaela Scutariu (Author), Liliana Pasarin (Author), Silvia Martu (Author)
• Format: Book
• Published: Romanian Society of Oral Rehabilitation, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The aim of this study was to evaluate the effects of melatonin supplementation accompanied by non-surgical periodontal therapy on serum melatonin, as well as inflammatory and oxidative stress markers in patients with type 2 diabetes with chronic periodontitis. The study was conducted on 50 subjects with periodontitis and diabetes mellitus type 2 (study group n = 25: patients with scaling and root planing + melatonin; control group = 25: patients with scaling and root planing + placebo). The melatonin, interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-α) and high-sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC) and total serum oxidant (TOS) levels were measured at baseline and after 8 weeks. Melatonin systemic intake reduced inflammation and oxidative stress markers in diabetic patients with chronic periodontitis.

Item Description

2066-7000
2601-4661