Profiling immune-evasion pathways in a Merkel cell carcinoma (MCC)
This case report presents the results of a pilot immuno-phenotypic evaluation of a MCPyV large T-antigen positive Merkel cell carcinoma (MCC). The overall results show a profound immunological imbalance in the MCC microenvironment. An evident prevalence of T-cell infiltration was accompanied by exte...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
Elsevier,
2021-11-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | This case report presents the results of a pilot immuno-phenotypic evaluation of a MCPyV large T-antigen positive Merkel cell carcinoma (MCC). The overall results show a profound immunological imbalance in the MCC microenvironment. An evident prevalence of T-cell infiltration was accompanied by extensive expression of regulatory T-cell markers, like CD25 and FOXP3. An active PDL1/PD1 immunosuppressive pathway is supported by the immunohistochemical findings. The macrophage inhibitory CD47/SIRPα pathway is up-regulated, although macrophage blockage seems to be mediated by a lymphocyte subpopulation expressing CD47, and not by MCC cells that were negative. The most striking finding was the extensive loss of HLA-class-I, and related β2-microglobulin and TAP-1 molecules expression, which predicts for impaired dendritic activation and cancer cell recognition by cytotoxic T-cells. A subset of infiltrating lymphocytes also overexpresses arginase and ectonucleotidases that further contributes to an immunosuppressive arginine-depleted and adenosine-rich microenvironment. |
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| Item Description: | 2772-736X 10.1016/j.hpr.2021.300561 |