Synthesis and Anti-Tumor Effects of Novel Pomalidomide Derivatives Containing Urea Moieties

• Main Authors: Yajie Guo (Author), Xi Wang (Author), Zhenzhen Wang (Author), Longfei Mao (Author), Jiahao Wang (Author), Lizeng Peng (Author), Guiqing Xu (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to explore novel immunomodulatory agents as anti-tumor drugs, we designed and synthesized a series of new pomalidomide derivatives containing urea moieties. Interestingly, in vitro biological experiments performed in several cancer cell lines showed that some of them displayed potent anti-t...