N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors

• Main Authors: Bernabucci Matteo (Author), Notartomaso Serena (Author), Zappulla Cristina (Author), Fazio Francesco (Author), Cannella Milena (Author), Motolese Marta (Author), Battaglia Giuseppe (Author), Bruno Valeria (Author), Gradini Roberto (Author), Nicoletti Ferdinando (Author)
• Format: Book
• Published: SAGE Publishing, 2012-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Pharmacological activation of type-2 metabotropic glutamate receptors (mGlu2 receptors) causes analgesia in experimental models of inflammatory and neuropathic pain. Presynaptic mGlu2 receptors are activated by the glutamate released...