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Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system

The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r>0.999, %RSD<2.0) in...

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Main Authors: José F. Ovalles (Author), Máximo Gallignani (Author), María R. Brunetto (Author), Rebeca A. Rondón (Author), Carlos Ayala (Author)
Format: Book
Published: Elsevier, 2014-04-01T00:00:00Z.
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Summary:The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r>0.999, %RSD<2.0) in the range of 7.7â77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate. Keywords: Amikacin, FTIR derivative spectrometry, Continuous flow system, Pharmaceutical preparation, Injection, Sulfate
Item Description:2095-1779
10.1016/j.jpha.2013.08.001

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