SBF-1 preferentially inhibits growth of highly malignant human liposarcoma cells
Frequent local recurrence and metastasis are generally involved in human liposarcoma, but the management is a challenge. There is an urgent need for improved effective therapy. In the present study, we reported that SBF-1, a steroidal glycoside, inhibited the growth of cultured highly malignant huma...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2018-12-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_2251ca39b2f64aa2bc01a7c95dc7b9cd | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Wei Chen |e author |
| 700 | 1 | 0 | |a Xuelong Qian |e author |
| 700 | 1 | 0 | |a Yue Hu |e author |
| 700 | 1 | 0 | |a Wei Jin |e author |
| 700 | 1 | 0 | |a Yunlong Shan |e author |
| 700 | 1 | 0 | |a Xianying Fang |e author |
| 700 | 1 | 0 | |a Yang Sun |e author |
| 700 | 1 | 0 | |a Biao Yu |e author |
| 700 | 1 | 0 | |a Qiong Luo |e author |
| 700 | 1 | 0 | |a Qiang Xu |e author |
| 245 | 0 | 0 | |a SBF-1 preferentially inhibits growth of highly malignant human liposarcoma cells |
| 260 | |b Elsevier, |c 2018-12-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2018.10.009 | ||
| 520 | |a Frequent local recurrence and metastasis are generally involved in human liposarcoma, but the management is a challenge. There is an urgent need for improved effective therapy. In the present study, we reported that SBF-1, a steroidal glycoside, inhibited the growth of cultured highly malignant human liposarcoma SW872-S cells in vitro and in vivo. SBF-1 down-regulated the phosphorylation of protein kinase B (AKT) and thus reduced cell adhesion to fibronectin and laminin. Then we found that SBF-1 inhibited the expression of oxysterol binding protein (OSBP) in SW872-S cells, indicating that OSBP may be involved in malignant liposarcoma cell survival. Cancer cell growth and AKT phosphorylation were inhibited significantly upon knockdown of OSBP in SW872-S cells in vitro. Taken together, these results suggest that SBF-1 causes an apparent loss of OSBP function in SW872-S cells, resulting in growth inhibition. Based on our findings, OSBP serves as a potential therapeutic target for human liposarcoma. Keywords: SBF-1, Malignant liposarcoma, SW872-S | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 138, Iss 4, Pp 271-278 (2018) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861318301956 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/2251ca39b2f64aa2bc01a7c95dc7b9cd |z Connect to this object online. |