Interaction of some new 2-(substituted-thio)-quinazolin-4-ones with molybdenum hydroxylases: A pharmacophore prediction
Background: Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases. Methods: Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity toward molybdenum hydroxylases. Results and conclus...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
SpringerOpen,
2015-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Background: Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases. Methods: Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity toward molybdenum hydroxylases. Results and conclusion: The tested quinazolines inhibited both xanthine oxidase and aldehyde oxidase enzymes in a competitive pattern with Ki values range of 66-753 μM. Pharmacophore prediction methodology was used to study the structure requirements of those inhibitors. |
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| Item Description: | 2314-7245 10.1016/j.fjps.2015.10.002 |