Interaction of some new 2-(substituted-thio)-quinazolin-4-ones with molybdenum hydroxylases: A pharmacophore prediction
Background: Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases. Methods: Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity toward molybdenum hydroxylases. Results and conclus...
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| Main Authors: | , , , |
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| Format: | Book |
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SpringerOpen,
2015-12-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_2258ab77a2be4ee0b5d6a38b2f47d9be | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Hussein I. El-Subbagh |e author |
| 700 | 1 | 0 | |a Alaa A.-M. |e author |
| 700 | 1 | 0 | |a Mohamed A. Al-Omar |e author |
| 700 | 1 | 0 | |a Fatmah A. Al-Omary |e author |
| 245 | 0 | 0 | |a Interaction of some new 2-(substituted-thio)-quinazolin-4-ones with molybdenum hydroxylases: A pharmacophore prediction |
| 260 | |b SpringerOpen, |c 2015-12-01T00:00:00Z. | ||
| 500 | |a 2314-7245 | ||
| 500 | |a 10.1016/j.fjps.2015.10.002 | ||
| 520 | |a Background: Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases. Methods: Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity toward molybdenum hydroxylases. Results and conclusion: The tested quinazolines inhibited both xanthine oxidase and aldehyde oxidase enzymes in a competitive pattern with Ki values range of 66-753 μM. Pharmacophore prediction methodology was used to study the structure requirements of those inhibitors. | ||
| 546 | |a EN | ||
| 690 | |a Quinazolin-4-ones | ||
| 690 | |a Xanthine oxidase | ||
| 690 | |a Aldehyde oxidase | ||
| 690 | |a Molybdenum hydroxylases | ||
| 690 | |a Pharmacophore prediction | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Future Journal of Pharmaceutical Sciences, Vol 1, Iss 2, Pp 50-56 (2015) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2314724515300170 | |
| 787 | 0 | |n https://doaj.org/toc/2314-7245 | |
| 856 | 4 | 1 | |u https://doaj.org/article/2258ab77a2be4ee0b5d6a38b2f47d9be |z Connect to this object online. |