Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response

• Main Authors: J. E. Zhang (Author), Kathrin Klein (Author), Andrea L. Jorgensen (Author), Ben Francis (Author), Ana Alfirevic (Author), Stephane Bourgeois (Author), Panagiotis Deloukas (Author), Ulrich M. Zanger (Author), Munir Pirmohamed (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic polymorphisms in the gene encoding cytochrome P450 (CYP) 4F2, a vitamin K oxidase, affect stable warfarin dose requirements and time to therapeutic INR. CYP4F2 is part of the CYP4F gene cluster, which is highly polymorphic and exhibits a high degree of linkage disequilibrium, making it diffi...