Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis

• Main Authors: Nan Li (Author), Tingting Zhao (Author), Yongtong Cao (Author), Haojun Zhang (Author), Liang Peng (Author), Yan Wang (Author), Xuefeng Zhou (Author), Qian Wang (Author), Jialin Li (Author), Meihua Yan (Author), Xi Dong (Author), Hailing Zhao (Author), Ping Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously reported that Tangshen formula (TSF), a Chinese herbal medicine for diabetic kidney disease (DKD) therapy, imparts renal protective effects. However, the underlying mechanisms of these effects remain unclear. Pyroptosis is a form of programmed cell death that can be triggered by the NL...