Characterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania major.

• Main Authors: Juliana Ide Aoki (Author), Adriano Cappellazzo Coelho (Author), Sandra Marcia Muxel (Author), Ricardo Andrade Zampieri (Author), Eduardo Milton Ramos Sanchez (Author), Audun Helge Nerland (Author), Lucile Maria Floeter-Winter (Author), Paulo Cesar Cotrim (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Tubercidin (TUB) is a toxic adenosine analog with potential antiparasitic activity against Leishmania, with mechanism of action and resistance that are not completely understood. For understanding the mechanisms of action and identifying the potential metabolic pathways affected by this d...