Minimal effective dose of bedaquiline administered orally and activity of a long acting formulation of bedaquiline in the murine model of leprosy.

• Ngā kaituhi matua: Aurélie Chauffour (Author), Nacer Lounis (Author), Koen Andries (Author), Vincent Jarlier (Author), Nicolas Veziris (Author), Alexandra Aubry (Author)
• Hōputu: Pukapuka
• I whakaputaina: Public Library of Science (PLoS), 2023-11-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

<h4>Background</h4>Bedaquiline (BDQ), by targeting the electron transport chain and having a long half-life, is a good candidate to simplify leprosy treatment. Our objectives were to (i) determine the minimal effective dose (MED) of BDQ administered orally, (ii) evaluate the benefit of c...