The use of high-density autologous chondrocytes implant for the treatment of hip joint chondral defects

• Main Authors: Raúl Torres-Eguia (Author), Juan Manuel López-Alcorocho (Author), Elena Rodríguez-Íñigo (Author), Isabel Guillén-Vicente (Author), Marta Guillén-Vicente (Author), María Elena Díaz-Navarro (Author), Lucía Áboli (Author), Tomás F. Fernández-Jaén (Author), Pedro Guillén-Garcia (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Introduction: In this work we describe the use of high-density autologous chondrocyte implantation (HD-ACI) to treat 2 patients with chondral defects in the hip. Case Presentation: Two male, 35- and 37-year-old, with chondral lesions and femoroacetabular impingement (FAI) were included. Chondrocytes were isolated expanded in vitro and then implanted at a density of 5 million cells per cm2 onto a type I/III porcine collagen membrane. None of the patients had surgery-derived complications. Pain disappeared in both cases at 6 months after surgery and was maintained until follow-up end (36 months). International Hip Outcome Tool (iHOT) score increased at 6 and 12 months and then leveled off until month 36.Three-year arthro-MRI showed the cartilage defects had been filled with a material similar to the surrounding healthy cartilage. Conclusion: HD-ACI is a safe and effective technique for focal cartilage lesion treatment in patients affected by evolved FAI.

Item Description

2667-2545
10.1016/j.jcjp.2022.100070