Evaluation of diallelic STR markers with inter-population allelic database for their usefulness in paternity trios in the Central Indian population

• প্রধান লেখক: Hirak Ranjan Dash (Author), Kamayani Vajpayee (Author), Radhika Agarwal (Author), Anubha Gang (Author), Ritesh Shukla (Author), Ankit Srivastava (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2021-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.
• Notes: 0301-4460; 1464-5033; 10.1080/03014460.2021.2014567
• Keywords: diallelic strs; paternity index (pi); paternity trios; allele frequency; database; Biology (General); QH301-705.5; Human anatomy; QM1-695; Physiology; QP1-981
• Source: Annals of Human Biology, Vol 48, Iss 7-8, Pp 605-613 (2021)

Background Most of the forensic DNA laboratories have migrated to new generation STR kits of 6 dye chemistry with more than 20 autosomal STRs. The population-specific databases of such STR markers are lacking in many regions. Aim To evaluate the effect of the inter-population database in 100 paternity trios with no inconsistencies at 23 STRs. Subjects and methods 100 paternity trios were evaluated considering inter-population allelic frequency values for calculation of Combined Paternity Index (CPI) and Probability of Paternity (POP). Results No significant variation (p < 0.05) among the allele frequencies at the interpopulation level was observed. The number of obligate alleles and the likelihood of transferring obligate alleles from the putative father showed a positive correlation (p < 0.005) with Power of Discrimination (PD), Polymorphic Information Content (PIC), Power of Exclusion (PE), Paternity Index (PI), Observed and Expected Heterozygosity (Ho and He), and a statistically significant negative correlation (p < 0.005) with Matching Probability (Pm). The average Combined Paternity Index (CPI) and Probability of Paternity (POP) did not show any statistically significant difference (p < 0.05) at the interpopulation level. Conclusion The allelic database showed no effect on the CPI and POP in 100 paternity trios. This suggests no urgent need for using population-specific databases for statistical evaluation of paternity trios without inconsistencies.