Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight

• Main Authors: Yunzhe Bai (Author), Takashi Tsunematsu (Author), Qibin Jiao (Author), Yoshiki Ohnuki (Author), Yasumasa Mototani (Author), Kouichi Shiozawa (Author), Meihua Jin (Author), Wenqian Cai (Author), Hui-Ling Jin (Author), Takayuki Fujita (Author), Yasuhiro Ichikawa (Author), Kenji Suita (Author), Reiko Kurotani (Author), Utako Yokoyama (Author), Motohiko Sato (Author), Kousaku Iwatsubo (Author), Yoshihiro Ishikawa (Author), Satoshi Okumura (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously demonstrated that type 5 adenylyl cyclase (AC5) functions in autonomic regulation in the heart. Based on that work, we hypothesized that pharmacological modulation of AC5 activity could regulate the autonomic control of the heart rate under micro- and hypergravity. To test this hypothe...