Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
Abstract.: Triazolam caused no significant increase in the total error at 0.05 and 0.1 mg/kg. However, at 0.2 mg/kg, it caused a significant increase in total error. Almost the same findings were observed with brotizolam and rilmazafone. That is, at 0.2 and 0.5 mg/kg of brotizolam, 0.5 and 1.0 mg/kg...
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Elsevier,
2006-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_2373823e6af84bdf9ebfac6ccc9a80b0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Takiguchi Atsushi |e author |
| 700 | 1 | 0 | |a Masuoka Takayoshi |e author |
| 700 | 1 | 0 | |a Yamamoto Yasuko |e author |
| 700 | 1 | 0 | |a Mikami Azusa |e author |
| 700 | 1 | 0 | |a Kamei Chiaki |e author |
| 245 | 0 | 0 | |a Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines |
| 260 | |b Elsevier, |c 2006-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.FPJ06008X | ||
| 520 | |a Abstract.: Triazolam caused no significant increase in the total error at 0.05 and 0.1 mg/kg. However, at 0.2 mg/kg, it caused a significant increase in total error. Almost the same findings were observed with brotizolam and rilmazafone. That is, at 0.2 and 0.5 mg/kg of brotizolam, 0.5 and 1.0 mg/kg of rilmazafone caused no significant increase in the total error. However, brotizolam at 1.0 mg/kg and rilmazafone at 2.0 mg/kg caused a significant increase in total error. Triazolam (0.05 mg/kg) and ethanol (1.0 g/kg) showed no significant effect on the numbers of errors when used alone separately, but the simultaneous use of triazolam and ethanol caused a significant increase in total error. Almost the same findings were observed with the coadministration of brotizolam (0.2 mg/kg) or rilmazafone (0.5 mg/kg) with ethanol. These results clearly indicate that all the short-acting benzodiazepines used in the study showed potentiation by ethanol in spatial memory deficits in mice. Keywords:: triazolam, brotizolam, rilmazafone, ethanol, radial maze | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 101, Iss 4, Pp 325-328 (2006) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319344378 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/2373823e6af84bdf9ebfac6ccc9a80b0 |z Connect to this object online. |