In vitro skin penetration of clobetasol from lipid nanoparticles: drug extraction and quantitation in different skin layers

• Main Authors: Luís Antônio Dantas Silva (Author), Stephânia Fleury Taveira (Author), Eliana Martins Lima (Author), Ricardo Neves Marreto (Author)
• Format: Book
• Published: Universidade de São Paulo, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clobetasol propionate (CP) is a potent topical corticosteroid that causes several cutaneous and systemic side effects. In the present work, CP was encapsulated in nanostructured lipid carriers (NLCs) to increase drug retention in the outer skin layers and improve the safety of topical therapy. NLCs...