Association between pro-inflammatory cytokine interleukin-33 and periodontal disease in the elderly: A retrospective study

• Päätekijät: Wellington Francisco Rodrigues (Tekijä), Camila Botelho Miguel (Tekijä), Niege Silva Mendes (Tekijä), Carlo José Freire Oliveira (Tekijä), Carlos Ueira-Vieira (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Wolters Kluwer Medknow Publications, 2017-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.
• Notes: 0972-124X; 10.4103/jisp.jisp_178_17
• Keywords: Elderly; interleukin-33; periodontal disease; Dentistry; RK1-715
• Source: Journal of Indian Society of Periodontology, Vol 21, Iss 1, Pp 4-9 (2017)

Background: Senescence is a multifactorial process that in humans may be accompanied by inflammation and immune dysfunction in the oral cavity. Notably, periodontal disease, considered one of the most common inflammatory disorders in the oral cavity, has also been linked to the onset of other chronic inflammatory diseases common in the elderly. Thus, investigating immunity and inflammation during senescence may not only illuminate the pathophysiology of periodontal disease, but also identify new therapeutic targets. Materials and Methods: To this end, we retrospectively and systematically reviewed studies of immune molecules associated with periodontal disease. These studies were identified in PubMed from three independent searches based on distinct sets of search terms. Results: The data highlight the need to further investigate inflammatory molecules involved in chronic periodontal disease in the elderly, but strongly suggest that interleukin (IL)-33 is involved. Indeed, various genetic and environmental factors appear to contribute to pathogenesis via IL-33. Conclusion: The IL-33 axis may be promising therapeutic target in elderly patients.