Exploring the kinetic selectivity of drugs targeting the β1‐adrenoceptor

• Main Authors: David A. Sykes (Author), Mireia Jiménez‐Rosés (Author), John Reilly (Author), Robin A. Fairhurst (Author), Steven J. Charlton (Author), Dmitry B. Veprintsev (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In this study, we report the β1‐adrenoceptor binding kinetics of several clinically relevant β1/2‐adrenoceptor (β1/2AR) agonists and antagonists. [3H]‐DHA was used to label CHO‐β1AR for binding studies. The kinetics of ligand binding was assessed using a competition association binding meth...