Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism

• Main Authors: Qi Sun (Author), Shiyue Li (Author), Junjun Li (Author), Qiuxia Fu (Author), Zhongyuan Wang (Author), Bo Li (Author), Shan-Shan Liu (Author), Zijie Su (Author), Jiaxing Song (Author), Desheng Lu (Author)
• Format: Bog
• Udgivet: BMC, 2018-05-01T00:00:00Z.
• Fag: article
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Abstract Background Homoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood. Methods We examined the effect of HHT on alternative splicing of Bcl-x and Caspase 9 in various cells using semi-quantitative reverse tran...