Methyl-α-D-glucopyranoside from Tulbaghia violacea extract induces apoptosis in vitro in cancer cells
Pro-apoptotic activity of Tulbghia violacea extracts was evaluated in order to understand the mechanisms of action that might be related to its traditional use as anticancer medicine. Apoptosis-guided purification was used to isolate active compound whose chemical structure was solved by using spect...
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| Format: | Book |
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Bangladesh Pharmacological Society,
2013-02-01T00:00:00Z.
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| Summary: | Pro-apoptotic activity of Tulbghia violacea extracts was evaluated in order to understand the mechanisms of action that might be related to its traditional use as anticancer medicine. Apoptosis-guided purification was used to isolate active compound whose chemical structure was solved by using spectros-copic, microanalysis and X-ray crystallography techniques. T. violacea extract kills Chinese hamster ovary cells, MCF7, and HeLa cells through the induction of apoptosis Methyl-a-D-glucopyranoside was identified as one of the main pro-apoptotic compounds present in T. violacea extract. This is the first time ever demonstration that T. violacea contains methyl-a-D-glucopyranoside, which selectively kills cancer cells through apoptosis mechanisms. |
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| Item Description: | 10.3329/bjp.v8i2.13717 1991-0088 |