Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy

• Main Authors: Eduardo Morato de OLIVEIRA (Author), Rafael Soares GUIEIRO (Author), Bárbara Lima CRUZ (Author), Maria Cássia Ferreira de AGUIAR (Author), Janine Mayra da SILVA (Author), Tarcília Aparecida SILVA (Author), Patrícia Carlos CALDEIRA (Author)
• Format: Book
• Published: Sociedade Brasileira de Pesquisa Odontológica, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Abstract Head and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for head and neck cancer treatment, compared with non-irradiated individuals. Total unstimulated saliva was collected for ELISA assay analysis of receptor activator for nuclear factor κ B (RANK) and its ligand (RANK-L), osteoprotegerin, matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2, vascular endothelial growth factor, and epidermal growth factor. Statistics were performed, and revealed that salivary RANK (p = 0.0304), RANK-L (p = 0.0005), matrix metalloproteinase-9/ tissue inhibitor of metalloproteinase-2 (p = 0.0067), vascular endothelial growth factor (p = 0.0060), and epidermal growth factor (p < 0.0001) were reduced in patients, compared with the control group. Osteoprotegerin did not differ between the groups (p = 0.3765). Salivary biomarkers did not differ according to radiotherapy completion time (p > 0.05). In conclusion, the lower output of the salivary molecules - essential for bone remodeling and tissue repair - may disrupt tissue homeostasis and play a role in the pathogenesis of the radiotherapy-induced deleterious effects in the oral cavity.

Item Description

1807-3107
10.1590/1807-3107bor-2021.vol35.0079