CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy

• Main Authors: Xiaoyu Wu (Author), Zijun Bai (Author), Hui Wang (Author), Hanqing Wang (Author), Dahai Hou (Author), Yunzhu Xu (Author), Guanqun Wo (Author), Haibo Cheng (Author), Dongdong Sun (Author), Weiwei Tao (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Copper-based nanomaterials demonstrate promising potential in cancer therapy. Cu+ efficiently triggers a Fenton-like reaction and further consumes the high level of glutathione, initiating chemical dynamic therapy (CDT) and ferroptosis. Cuproptosis, a newly identified cell death modality that repres...